
Terapia combinada

The Cyprus Protocol – Multimodal Combination Therapy for Long COVID, Post-Vac and Chronic Illnesses
In the field of HIV and cancer, combination therapy is one of the most successful forms of treatment – often it is the gold standard in the specific field.
Junto con colaboradores de todo el mundo y a través de nuestra experiencia clínica combinada con la investigación dirigida por los pacientes, hemos desarrollado el primer protocolo multimodal de terapia combinada para COVID prolongado, síndrome postvacacional y enfermedades crónicas.
We named it after it’s place of origin:
Protocolo de Chipre
Below you find a dynamic list of the protocol’s elements and a treatment schedule example.
Afecciones que tratamos

¿Qué enfermedades tratamos en el Centro de Aféresis con el Protocolo de Chipre?
He aquí algunos ejemplos (no exhaustivos) de las afecciones más comunes que tratamos en nuestra clínica:
- Covid largo (PCS)
- Post-Vac (PVS)
- Síndromes postinfecciosos / postvirales
- POTS
- EDS
- MCAS / IBS / SIBO
- PANS / PANDAS
- PIMS / MIS-C
- Enfermedades autoinmunes
- Síndrome de fatiga crónica
- Afecciones reactivadas (EBV, Mono, CMV, Herpes, Babesia, Bartonella)
- Enfermedad de Lyme
- Fibromialgia
- ME/SFC
- Esclerosis múltiple
- Lupus
- Artritis reumatoide
- Síndrome de Sjögrens
- Raynaud’s Disease
- Esclerodermia
- Alzheimer
- Parkinson
- SFN / Neuropatía
- MCS
- Otras afecciones con problemas inflamatorios, autoinmunes y de microcirculación, así como afecciones con toxinas o patógenos en la raíz.
Elementos del Protocolo de Chipre
Haga clic en cada elemento del Protocolo de Chipre para más detalles
El protocolo debe individualizarse para cada paciente.
With the new diagnostic tools of our D-T-R model – Continous Diagnostics we are now able to apply targeted treatments with higher precision.
Independent of the treatment a patient is undergoing – without adapted nutrition for the three treatment phases pre-treatment, on-treatment and post-treatment, the achievable results differ.
This is why we base our Combination Therapy on individual and personalized nutrition plans for every patient, based on the results of blood panel test and food intolerance test that show IgG reactions to 287 foods (vegetables, fish & seafood, fruits, spices, nuts, legumes, meat, egg & milk, cereals & seeds, nuts, coffee & tea and novel foods).
Our Clinical Nutritionist Chryso Zorbas will hold your hand nutritionally from day one and guide you along the therapy with a personalized diet plan that will enhance your recovery process. Needless to say that our Health Coaching (see below) is a perfect match and goes hand in hand with our Clinical Nutrition Supervision.
Learn more about Clinical Nutrition Supervision here
Chronic Illness is very complex – having an expert patient turned professional Health Coach by your side throughout your whole journey offers priceless knowlege and guidance.
Our Health Coach Tanja Walser will coach you from day one and guide you along the therapy with a personalized coaching plan that will include all the dos and don’ts and give you a headstart despite brainfog, anxiety or other symptoms you are battling with.
Learn more about Health Coaching here
Our most effective treatments to date: At the core of our multimodal Combination Therapy are several forms of Therapeutic Apheresis’ – special blood purifications by precipitation/adsorption/filtration procedures. They serve to treat microcirculation / blood flow issues (microclots are removed, blood flow increased) and removes pathogenic or disease-sustaining proteins as well as protein-bound substances and autoantibodies from the blood. Amongst other substances environmental toxins, inflammation proteins, viral spike protein, cholesterol + autoantibodies are removed
Learn more about H.E.L.P. Apheresis
Learn more about Inuspheresis®
Learn more about Immunoadsorption
In some cases H.E.L.P. Apheresis will be combined with TPPE – Therapeutic Partial Plasma Exchange
El sistema de hipertermia de cuerpo entero Heckel HT3000 permite un aumento selectivo de la temperatura central del cuerpo, desde una fiebre leve hasta una fiebre alta. La hipertermia corporal no sólo trata los síntomas, sino que también pretende restablecer un mejor control regulador en todo el organismo. Los sistemas de hipertermia de cuerpo entero de Heckel son una contribución significativa a los tratamientos de una amplia gama de enfermedades y afecciones, que van desde la promoción de la salud hasta el alivio del dolor y el tratamiento de apoyo en afecciones crónicas y cáncer. En Long Covid y Post Vac, la liberación de receptores y la desintegración de proteínas patógenas son otros de los efectos deseados.
Long Covid and many other Chronic Illnesses are at their root an endothelitis/vasculitis with severe inflammation, combined with hypercoagulation and often viral persistence. Autoimmunity components can be involved too.
IV treatments work directly where needed the most: in the blood vessels in the desired concentration.
IV/Intravenous therapies that are used in our Long COVID and Chronic Illnesses Combination Therapy are:
– IV Vitamin C (Reducing inflammation)
– IV Glutathione (Antioxidant)
– IV Multivitamin Protocol (Balancing deficiencies)
– IV NAD+ (Metabolism/mitochondria benefits)
– IV Alpha Lipoic Acid (Metabolism/nerve pain reduction)
– IV Zinc (Reducing inflammation, speeding up recovery)
– IV Magnesium (Electrolyte reducing fatigue and anxiety)
– IV NAC (Reduces brainfog/relieves respiratory discomfort)
– IV Taurin (Is Cytoprotective (cell protective) and detoxyfying)
– IV Arginine (Increases elasticity of blood vessels and increases blood flow)
– IV Lysine (Increases cell healing and wound healing)
– Other IVs: Iron, Selenium, Amino Acids, Minerals and more
Peptide Therapy:
Peptide therapy offers a groundbreaking approach to restoring balance and vitality for individuals struggling with long COVID, post-vaccine syndrome, and chronic illnesses. Peptides are short chains of amino acids that act as signaling molecules in the body, promoting tissue repair, immune modulation, and cellular rejuvenation. By targeting underlying dysfunctions such as inflammation, impaired immunity, and mitochondrial damage, peptide therapy can accelerate recovery, enhance energy, and support overall wellness. Tailored to each patient’s unique needs, this therapy provides a safe and effective way to improve quality of life, fostering the body’s natural ability to heal and thrive.
Find more information on our IV Therapy and Peptide Therapy click here for iv therapy and peptide therapy
Chelation Therapy:
Chelation therapy is a medical intervention characterized by the administration of chelating agents, substances with a high affinity for certain metal ions, to facilitate the removal of heavy metals and minerals from the body.
Find more information on Chelation Therapy here
Our Nutraceutical treatment strategy for the detoxification from viral spike protein involves the following 4-step process:
The first step is preventing reinfection by blocking the receptors on host cells, which the virus and viral spike protein use to gain entry.
The second step is to help restore autophagy processes, which are the body’s natural way of cleaning out damaged cells and regenerating new ones.
The third step aids in liberating viruses and viral spike proteins by selectively targeting infected or transfected cells.
The fourth step facilitates the sequestration of viral spike protein and virus, effectively removing them. The most efficient way to do this is H.E.L.P. Apheresis and where that is not possible, the use of Algerol is indicated.
This comprehensive approach aims to remove the spike protein from the body safely while also enhancing the immune system’s ability to prevent further infections.
At the end of our therapy course we add a 3-6 months NAC Augmented protocol.
Find more about Nutraceutical Therapy here
Medication and supplement protocols increase H.E.L.P. Apheresis results further and can be used to treat patients symptom-specific. The protocols include Antiviral Protocols and Anticoagulation Protocols.
Symptoms the medication protocols focus on are:
– Viral persistence
– Persisting hyper coagulation
– MCAS (mastcell activation syndrome), often combined with gastroparesis
– Endothelial damage, often combined with hypercholesterolaemia
– Neuro inflammation/brain inflammation
– Fatigue, PEM often combined with mitochondrial dysfunction
– Insomnia
– Induced anxiety/paranoia/depression
– Reactivated viruses
– Others
Find more information on Antiviral Therapy and Anticoagulation Therapy
Anxiety, Depression, PTSD, Chronic Pain and Fatigue Therapy for Long Covid and Chronic Illness
Are you or a loved one struggling with the lingering effects of Long Covid or battling the relentless challenges of chronic illness? At the Apheresis Center we understand the toll these conditions can take on both your physical and mental well-being. That’s why we offer revolutionary approaches to treatment.
Find more about Depression & Anxiety Therapy here
Colon Hydrotherapy, also known as colonic irrigation, constitutes an internal cleansing procedure designed to rid the colon of deleterious waste materials. This therapeutic intervention serves as a rapid and highly efficient means of detoxification for the body. The mild internal hydration expeditiously eliminates pathogenic toxins by leveraging the natural peristaltic movements, further facilitated by abdominal massage. Notably, this process has implications for individuals with symptoms that present similar to Mast Cell Activation Syndrome (MCAS), as it influence the systemic responses associated with this symptoms often triggered by Long Covid, Post Vac or other Chronic Illnesses.
Our Medical Team has designed a MCAS treatment package which is tailored to each patient individually
MCAS Blood Test (CCL2, IL-6, IL-8, IL-31, IL-33, TNF-alpha, Tryptase)
Nutrition Plan
3x Colon Hydrotherapy, ozonated treatment
3x Leaky Gut IV (L-Lysin, Taurin, L-Alanyl-Glutamin, Glycin, Cholinchlorid, Magnesiumchlorid, Kaliumchlorid
MCAS Medication Plan including Nutraceuticals and Nanozeolites
Find more information on Colon Hydrotherapy and MCAS Treatment here
The application of Intravenous Immunoglobulin (IVIG, if subcutaneously administered also called SCIG)) and monoclonal antibodies (mABs) like Evusheld or Xevudy (Sotrovimab) represents a new area in treating Long Covid, Post Vac and Chronic Illnesses. These conditions involve complex immune dysregulation and inflammatory responses. IVIG is a concentrated preparation of immunoglobulins derived from pooled human plasma.
Monoclonal antibodies, designed to target specific components of the immune response, present another avenue for intervention. Both IVIG and mABs are being investigated for their potential to restore immune homeostasis.
The current official indications include symptoms present in chronic illness and many post-viral conditions: Myo- and Pericarditis, Small Fiber Neuropathy but also acute/severe conditions like Sepsis.
Find more about IVIG and mABs Therapy here
For specific symptoms and subgroups after H.E.L.P. Apheresis treatment these treatments can speed up and enforce the recovery process. (Note: HBOT is only administered after H.E.L.P. Apheresis therapy. Ozone-EBOO is only administered after H.E.L.P. Apheresis and only in special cases)
Find more information on Hyperbaric Oxygen Treatment here and Cryotherapy here
Mitochondrial therapy, also known as metabolic correction, is an emerging approach in the management of Long Covid and chronic illnesses characterized by fatigue. This therapy aims to enhance mitochondrial function, which is often impaired in these conditions, by providing specific nutrients and cofactors that support cellular energy production. Key substances used in mitochondrial therapy include NAC (N-Acetyl L-Cysteine), L-Serine, L-Carnitine, Nicotinamide Riboside (NR), L-Choline, NT Factor, and NADH. These compounds work synergistically to replenish depleted cellular antioxidants, enhance mitochondrial biogenesis, improve fatty acid metabolism, and restore ATP production, ultimately helping to alleviate fatigue and improve overall cellular health in individuals suffering from prolonged symptoms of Long Covid and other chronic fatigue-related conditions.
Find more about Mitochondrial Therapy here
Many of our last year’s patients had to come back to us for another course of H.E.L.P. Apheresis and Combination Therapy treatment, because they reinfected with Covid and were thrown back to experiencing Long Covid symptoms. This is why we started giving out ‘Early Treatment packages’ which avoid exactly that. Our prescribing doctors will supply you with everything needed to get through your next reinfection without risking to worsen again.
Ejemplo de plan de tratamiento
Visualización de las opciones de tratamiento del Protocolo de Chipre
In the below PDF you find a visualisation of available treatments (this is solely for the purpose of demonstrating available options – this NOT a real life case/treatment schedule)
Recomendación: Descargar y ampliar para ver los detalles.
Fuentes científicas y estudios sobre aféresis terapéutica para Covid prolongada/Postvac y otras afecciones
H.E.L.P. Apheresis
- Gavin Diagnóstico y tratamiento de enfermedades infecciosas
- Researchgate
- Springer
- Fronteras
- Aféresis terapéutica y diálisis
- Revista de Trombosis y Hemostasia
- Springer Nature
- The American Journal of Medicine
- PubMedCentral
- Ciencia
A collection of sources which have published success rates can be found at the Long Covid Apheresis Community (LCA Community): https://lcacommunity.org/research
Los resultados publicados por la Comunidad de ACV han sido confirmados en el ISFA2023:
ISFA 2023 (Conferencia Mundial de la Sociedad Internacional de Aféresis)
Inusféresis
Science 2024 – new study looking at the relation between microclots and immune damage in Long Covid:
Quote: ‘…coagulation in Long Covid is indicated by the detection of circulating fibrinolysis-resistant microclots that are enriched in vWF, C7, acute-phase serum amyloid proteins, and fibrin, proteins identified in the proteomics screen by Cervia-Hasler et al. as contributors to Long Covid.’
Full study: https://www.science.org/doi/10.1126/science.adn1077
En términos más sencillos, este estudio investiga las razones de la persistencia de los síntomas en algunas personas tras recuperarse de la COVID-19, una afección conocida como Covid largo. Los investigadores descubrieron que los pacientes con Covid largo presentan una activación continua del sistema inmunitario, en concreto del sistema del complemento, que conduce a la inflamación y la formación de coágulos sanguíneos. A diferencia de lo que ocurre durante la COVID-19 aguda, en la que el hígado desempeña un papel fundamental en las respuestas inmunitarias, en la Covid Larga la inflamación parece estar más localizada, afectando a tejidos y células inmunitarias. El estudio sugiere que esta activación inmunitaria persistente, sobre todo en el sistema del complemento, contribuye a los síntomas que experimentan los pacientes de Covid larga.
Los investigadores identificaron proteínas específicas, como la pentraxina 3 y los componentes del complemento, que están asociadas al Covid Largo. El sistema del complemento, cuando no está controlado, puede causar daños en las células y los vasos sanguíneos. En los pacientes con Covid Larga, hay pruebas de una activación excesiva del complemento, que conduce a la inflamación y a la formación de microclot . Este estado inflamatorio continuo, incluso en ausencia de coagulación sanguínea generalizada, puede explicar los síntomas persistentes observados en el Covid Largo, como fatiga y problemas cognitivos.
Además, el estudio halló desequilibrios en factores relacionados con la coagulación sanguínea, lo que sugiere un posible mecanismo de tromboinflamación en el Covid Largo. Aunque no se conocen con exactitud las causas de la activación inmunitaria y la coagulación persistentes en el Covid Largo, el estudio indica que el tratamiento del Covid Largo podría dirigirse a componentes específicos de los sistemas inmunitario y de coagulación.
H.E.L.P. Apheresis and Inuspheresis® address most if not all of the above. Microclots, Hypercoagulation, Inflammation, Pathogens to list just a few modes of action of H.E.L.P. Apheresis and Inuspheresis® . The rest can be addressed by other elements of the multimodal Combination Therapy of ‘The Cyprus Protocol’.
Encontrará amplia información en nuestra entrada del blog sobre los diferentes tipos de aféresis y qué tipo es adecuado para cada fin AQUÍ
Nuestro Centro de Aféresis y H.E.L.P. Aféresis en TV
ITV News, BBC News, France 2 y WDR TV. Extractos de algunos de los reportajes sobre nuestro Centro de Aféresis y H.E.L.P. Aféresis para Post/Long Covid, Síndrome Post Vac y Enfermedades Crónicas.
Testimonios
Jeremy Smith, Long Covid, Estados Unidos
‘I had 4 Help Apheresis treatments last year in Germany. They brought me back to 80% of my former capacity.
The Apheresis Center is a totally different experience and I am super happy I chose Cyprus. It is very different from Germany. The doctors, nurses and the whole team are doing everything to bring me back to my full capacity, their knowledge about Long Covid and the individually adapted treatment is great – a real concierge medicine experience! I missed home last year in Germany – here in Cyprus not a single day, we even extended our stay and will come back next year for holidays!’
You can read and watch Jeremy’s full story here: Full Video
Katrina Krulla, Long Covid, Estados Unidos
‘I have had some amazing results with H.E.L.P. Apheresis for my Long Covid – my 6th treatment got me back to feeling 75% to 90% recovered. Larnaca was truly an amazing place for recovery. Also the great community for support that formed with others getting treatment was so wonderful. It was so nice to have a team of people helping you that “got it” and believed you in addition to being with others suffering the same life changing illness.’
Patricia Price, ME/CFS, Reino Unido
Patricia padece MECFS grave desde 2015:
‘My Help Apheresis treatment improved my ME by 80%. Help Apheresis took me from being mostly bed bound 23 hours a day – I could not be upright without my heart jumping to 170 beats per minute, even higher if I tried to have a shower – to being able to be upright and be mobile almost every day. It changed my life! I can now manage my own life again. I can go outside again and I was able to gain weight and can now eat three solid meals a day again!
You can watch Patricia’s full story here: Full Video
Landen Williams, Long Covid, EE.UU.
Landen luchaba contra la respiración, la ansiedad, la niebla cerebral y otros síntomas antes de que le tratáramos con H.E.L.P. Aféresis. Varios meses después del tratamiento, Landen ha recuperado el 70% de su estado anterior; los últimos síntomas que persisten parcialmente son la fatiga y la MEP. Los está tratando con terapia combinada. El video de arriba es una versión corta / extracto de su aparición en 1819 Noticias (Fuente: 1819news)
Combination Therapy and H.E.L.P. Apheresis do not achieve the same results in the same time frame for different patients. From our clinical experience we have seen similar success rates as presented on the ISFA 2023 (World Conference of the International Society for Apheresis) – 80% success rate with results varying from smaller improvements to being fully curative. The majority of patients saw a significant improvement. Long Covid, Post Vac and CI are umbrella terms with different subsets – no patient presents the exact same symptoms set.
The time frame in which patients see results also vastly differs – from first treatment to several months.
Documental de ARTE TV "Long Covid - Curación en Chipre
Documental de ARTE TV "Long Covid - Healing in Cyprus" sobre nuestro Centro de Aféresis
El documental se emitió en junio de 2024. Un equipo de periodistas de la cadena de televisión europea ARTE TV acompañó a tres de nuestros pacientes de Covid Largo y Síndrome Post Vac y les entrevistó a ellos y a nuestro equipo del Centro de Aféresis. Aquí puede ver un extracto del documental, que también es fácil de ver para pacientes con disfunción cognitiva, niebla cerebral y migrañas relacionadas. Audio en inglés por Dubly.
Desde que se rodó el documental, se han hecho nuevos descubrimientos científicos, puede encontrar los últimos estudios publicados aquí.
Markus ha publicado una entrada en su blog aquídonde describe los avances y actualizaciones desde que se filmó el documental.

